The OGTT debate continues: a pragmatic clinical approach should prevail

The antidepressant debate continues

In her March 2002 editorial, Dr Moncrieff raises doubts about the efficacy of antidepressant drugs, and argues that side-effects of the active drug may explain some of the differences owing to the associated increased expectancy of a positive effect. Our 24-week study (Malt et al, 1999) comparing the efficacy of empathic primarycare counselling and support combined with placebo, a selective ser...

The antidepressant debate continues

In her March 2002 editorial, Dr Moncrieff raises doubts about the efficacy of antidepressant drugs, and argues that side-effects of the active drug may explain some of the differences owing to the associated increased expectancy of a positive effect. Our 24-week study (Malt et al, 1999) comparing the efficacy of empathic primarycare counselling and support combined with placebo, a selective ser...

When Should Precaution Prevail

DSM-5: the debate continues

We are fortunate to have invited commentaries from the laboratories of Dr Cathy Lord and Dr Fred Volkmar offering their perspectives on the new Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria for the autism spectrum. Both commentaries note how DSM-5 collapses the earlier diagnostic categories of the pervasive developmental disorders into a single category of autism spectr...

Yeast apoptosis debate continues

Yeast apoptosis debate continues east, as a unicellular organism, would seem to benefit most from self-preservation. But yeast altruism, in the form of apoptosis, is a new-found, if controversial, field of study. Many doubt the validity of experiments supporting programmed cell death in yeast and call for better controls. In this issue, the debate continues with two new articles that suggest th...